education

Max Planck Florida Institute for Neuroscience Jupiter, FL
  • Advisor: Dr. Yingxue Wang
  • International Max Planck Research School fellow
  • Working manuscript: Rapid locus coeruleus dopamine shapes CA1 dynamics for time/distance estimation
University of Cambridge Cambridge, UK
  • Magdalene College
  • Jardine Scholar; Bundy Scholarship; College Prize for Natural Sciences; Magdalene Scholar

research experience

Wang Lab, Max Planck Florida Institute for Neuroscience Jupiter, FL

I study how phasic locus coeruleus dopamine release tunes hippocampal CA1 dynamics during memory-guided navigation. The project combines virtual-reality behaviour, extracellular recordings, optogenetics, local pharmacology, two-photon dopamine and calcium imaging, Python analysis pipelines, and computational modelling.

Paulsen Lab, University of Cambridge Cambridge, UK

Undergraduate thesis on dopamine facilitation of CA3-CA1 behavioural time-scale plasticity. Used whole-cell patch-clamp electrophysiology to study how dopamine changes hippocampal long-term potentiation rules; thesis received a First-Class mark.

Fisher Lab, Queen Square Institute of Neurology, UCL London, UK

Genetics Society Genes and Development Summer Studentship. Studied cathepsin B activity deficits in mouse models of Down syndrome-associated Alzheimer's disease pathology using western blotting and protein activity assays.

publications & preprints

Luo D, Cao J, Heldman R, Tian L, Wang Y. Rapid locus coeruleus dopamine shapes CA1 dynamics for time/distance estimation. Manuscript in preparation.
Wu Y, Mumford P, Noy S, Cleverley K, Mrzyglod A, Luo D et al. (2023). Cathepsin B abundance, activity and microglial localisation in Alzheimer's disease-Down syndrome and early onset Alzheimer's disease: the role of elevated cystatin B. Acta Neuropathologica Communications 11, 132. doi:10.1186/s40478-023-01632-8

conference presentations

2026
Locus coeruleus dopamine rapidly modulates CA1 dynamics to sharpen goal-directed navigation. COSYNE 2026, selected poster.
2025
Locus coeruleus dopaminergic modulation of CA1 shapes behavioural timescale dynamics for time integration. Lake Conference, Seattle, WA.
2025
An LC-CA1 circuit for initiating path integration. Sunposium, West Palm Beach, FL.
2024
Locus coeruleus regulates hippocampus-dependent integration at single-trial level. Memory Formation Forum, MPFI, Jupiter, FL.
2024
Phasic locus coeruleus activity regulates hippocampal neuronal dynamics during path integration. Scientific Advisory Board Meeting, MPFI, Jupiter, FL.
2023
Phasic locus coeruleus activity regulates hippocampal integration. MPFI Retreat, Key Largo, FL.

skills

Programming
Python, MATLAB; working knowledge of R, Java, and SQL
Neuroscience techniques
Extracellular electrophysiology, whole-cell patch-clamp electrophysiology, optogenetics, two-photon imaging, genetically encoded dopamine and calcium sensors, local pharmacology, histology
Data analysis
Behavioural analysis, neural time-series analysis, spike-train analysis, two-photon image analysis, generalised linear models, computational modelling, figure generation
Languages
Cantonese (native), Mandarin Chinese (native), English (fluent); conversational German and Spanish

awards & fellowships

  • International Max Planck Research School fellow, Max Planck Florida Institute for Neuroscience
  • Jardine Scholar, University of Cambridge
  • Bundy Scholarship and College Prize for Natural Sciences, Magdalene College, University of Cambridge
  • Magdalene Scholar, University of Cambridge
  • Genes and Development Summer Studentship, Genetics Society

outreach & science communication

Translator
Writer, editor, proofreader and translator

Founded and led the Neuro-Frontier (神经前研) section, co-founded the Neuromancing podcast team, and wrote, edited, proofread, and translated authorised science writing from outlets including Quanta, Nautilus, and Aeon.

Science journalist

Wrote weekly news and a print feature on the Accelerating Research on Consciousness (ARC) initiative, interviewing researchers including Anil Seth and Cyriel Pennartz.

Last updated May 2026